4 down
Conk
out
drunk,
get
up
and
use
loo?
Not
us!
(2,2,5)
Conk out drunk, get up and use loo? Not us! (2,2,5)
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The definition is at the beginning of the clue.
How the clue works
Conk out is the definition. Take "get up and use loo", remove both Us ("not us"), leaving the letters GETP + SELOO, then anagram them ("drunk") to get GO TO SLEEP.