2 down
Disease
can
be
horrific
if
ignored
by
family
member
(9)
Disease can be horrific if ignored by family member (9)
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The definition is at the beginning of the clue.
How the clue works
Disease is the definition. Take "horrific" and drop the IF ("if ignored"), leaving the letters H, O, R, R, I, C, which anagram to CIRRHO. Then add SIS (a family member, short for sister) to finish it off.