21 down
Key
tenant
initially
lost?
(5)
Key tenant initially lost? (5)
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The definition is at the beginning of the clue.
How the clue works
Look at Key — that's your definition, the ENTER key on a keyboard. The wordplay gives you the same answer a different way: tenant here is RENTER (a synonym), and initially lost means you drop the first letter R, leaving you with ENTER.