The definition is turned up, as in a retroussé nose that curves upward. Trousers gives you your anagram fodder, but first lost at the start tells you to drop the initial letter T, leaving ROUSERS — then eventually points to the last letter of "turned", which is D... actually, scratch that: take all the letters of trousers and add E (the last letter of "the", indicated by eventually), giving you nine letters to jumble up, with turned doing duty as the anagram indicator. Shake TROUSERS + E about and you land squarely on the answer.