25 down
Luckily
avoid
both
cold
and
high
temperature
(5)
Luckily avoid both cold and high temperature (5)
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The definition is at the beginning of the clue.
How the clue works
Luckily avoid is your definition — think "cheat death", meaning to narrowly escape something. For the wordplay, C (cold) is placed in front of HEAT (high temperature) to build the answer letter by letter.