22 across
Sickness
resulting
from
excrement,
mostly,
around
hovel
(7)
Sickness resulting from excrement, mostly, around hovel (7)
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The definition is at the beginning of the clue.
How the clue works
Look at Sickness — that's your definition. For the wordplay, excrement, mostly gives you CRAP with its last letter dropped, leaving CRA, and that goes around hovel, which is HOLE, to give you C + HOLE + RA all tucked together.