4 down
What?
Bottle
upended
spilling
a
bit
of
fluid?
That’s
painful
(7)
What? Bottle upended spilling a bit of fluid? That’s painful (7)
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The definition is at the end of the clue.
How the clue works
The definition is That's painful. The wordplay takes EH (meaning "what?") and CARAFE (a type of bottle), then removes the F (a "bit of fluid" — the first letter of "fluid"). That gives EH + CARAE. Since this is a down clue, "upended" tells us to reverse the whole lot: EARAC + HE, giving EARACHE.