22 across
Nuts
in
games
headphones
(6)
Nuts in games headphones (6)
hints
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The definition is at the beginning of the clue.
How the clue works
The definition is Nuts, giving us PECANS. The wordplay is a charade: PE comes from "games" (as in Physical Education), and CANS is slang for "headphones". Put them together and you get PE + CANS = PECANS.