21 across
British
heavyweight
losing
no
time
with
friend
in
a
cruel
manner
(8)
British heavyweight losing no time with friend in a cruel manner (8)
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The definition is at the end of the clue.
How the clue works
The definition is in a cruel manner. "British heavyweight" gives us Frank BRUNO, the famous British boxer. "Losing no" tells us to remove NO from BRUNO, leaving BRU. Then T comes from "time", and ALLY means "friend". Put them together — BRU + T + ALLY — and you get BRUTALLY.