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Eye
problem
from
middle
of
last
year
(4)
Eye problem from middle of last year (4)
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The definition is at the beginning of the clue.
How the clue works
Look at Eye problem — that's your definition, a nasty little eyelid infection. The rest of the clue asks you to pull out the letters from the middle of "laST YEar", with "from middle of" acting as the hidden word indicator.