3 down
To
begin
journey,
addled
Edith
Wharton
losing
direction,
first
and
last
(3,3,4)
To begin journey, addled Edith Wharton losing direction, first and last (3,3,4)
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The definition is at the beginning of the clue.
How the clue works
The definition is To begin journey. The wordplay takes EDITH WHARTON and removes "direction, first and last" — the first letter W (a compass direction) and the last letter N (also a compass direction) from the surname WHARTON. This leaves the letters EDITH HARTO, which when "addled" (anagrammed) give HIT THE ROAD.