6 across
Wine
tossed
back
during
Cinco
de
Mayo
(5)
Wine tossed back during Cinco de Mayo (5)
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The definition is at the beginning of the clue.
How the clue works
The definition is Wine — MEDOC being that well-known Bordeaux region. Now look at "CinCO DEMayo" and you'll spot CO DEM hiding in there, which when tossed back (reversed, as the clue tells you) gives you your answer.