22 across
Tosspot
taking
up
a
largely
synthesised
instrument
(10)
Tosspot taking up a largely synthesised instrument (10)
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The definition is at the end of the clue.
How the clue works
The definition is instrument, referring to a sousaphone. "Tosspot" gives SOUSE (a drunkard), and "synthesised" clues PHON(Y), with "largely" telling us to drop the last letter, leaving PHON. "Taking up a" means SOUSE takes in A and PHON, so A PHON is placed inside SOUSE to give SOUS-A-PHON-E.