28 across
Centaurs
cast
out
of
a
pre-Roman
state
(8)
Centaurs cast out of a pre-Roman state (8)
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The definition is at the end of the clue.
How the clue works
The definition is pre-Roman state — that ancient civilisation that came before Rome. "Cast out of a" signals an anagram, and sure enough, scramble the letters of CENTAURS and they fall neatly into place.