21 down
One
fond
of
chow
initially
fond
of
cartoon
dog
…
(6)
One fond of chow initially fond of cartoon dog … (6)
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The definition is at the beginning of the clue.
How the clue works
So One fond of chow gives us a food lover. The word "initially" tells you to take just the first letters of "fond" and "of" — that's F and O — then tack on ODIE, the famous cartoon dog from Garfield, and you've got your six letters.