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The
river
that
moves
vast
quantities
of
goods
(6)
The river that moves vast quantities of goods (6)
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The whole clue is the definition (& lit or double definition).
How the clue works
The river that moves vast quantities of goods is doing everything here — it's a cryptic definition with a cheeky double meaning baked right in. You're being nudged to think of both a famous South American river and the online retail behemoth that ships an extraordinary volume of parcels around the world.