25 across
Queasy
one,
relative
gulping
oxygen
is
in
a
state
(10)
Queasy one, relative gulping oxygen is in a state (10)
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The definition is at the end of the clue.
How the clue works
The definition is in a state — specifically, a resident of Illinois. You've got ILL (queasy) then I (one), followed by NAN (relative) swallowing O (oxygen) to give you N-OIS-AN, and then IS tacked on at the end, all of which strings together to make the full ten letters.