4 down
Very
uplifting
southern
puzzle
(5)
Very uplifting southern puzzle (5)
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The definition is at the end of the clue.
How the clue works
The definition is puzzle — a rebus being that picture-based kind where symbols stand in for words. Take "very" as UBER, flip it upwards ("uplifting") to get REBU, then tack on S for southern and you're done.