16 across
Just
over
50
in
US
city
(4)
Just over 50 in US city (4)
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The definition is at the beginning of the clue.
How the clue works
The definition is Just, meaning "only." For the wordplay, take NY (your "US city," New York) with O for over to get ONY, then slot in L (Roman numerals for 50) to get O-N-L-Y.