21 down
Entry
of
‘female’
in
dictionary
rejected
by
eastern
writer
(5)
Entry of ‘female’ in dictionary rejected by eastern writer (5)
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The definition is at the end of the clue.
How the clue works
The definition is writer, your man Daniel Defoe. You take "dictionary" as OED, flip it (that's the "rejected" bit) to get DEO, drop the "entry of 'female'" — just the letter F — inside it to get DEFO, then tack eastern's E on the end.